منابع مشابه
Tracer Kinetics Modeling Basics: Model Formulation
Introduction With the advances in fast MR imaging techniques, it is possible to monitor the traversal of a MR contrast agent within tissues at short time intervals (of the order of a few seconds or less), thereby allowing the possibility to study blood flow at the tissue level. Dynamic contrastenhanced MRI (DCE MRI) is emerging as a promising approach for in vivo assessment of tissue microcircu...
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Three major models (from Tofts, Larsson, and Brix) for collecting and analyzing dynamic MRI gadolinium-diethylenetriamine penta-acetic acid (GI-DTPA) data are examined. All models use compartments representing the blood plasma and the abnormal extravascular extracellular space (EES), and they are intercompatible. All measure combinations of three parameters: (1) kPSp is the influx volume transf...
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In tracer kinetic studies for extracting biological information, measurement noise and error in the kinetics could affect the reliability of the estimated biological parameters. While the effect of statistical noise has been studied extensively before, the effect of outliers has not been addressed as much. In this study, we described an algorithm for detecting and removing outliers. Computer si...
متن کاملBlood Tracer Kinetics in the Arterial Tree
Evaluation of blood supply of different organs relies on labeling blood with a suitable tracer. The tracer kinetics is linear: Tracer concentration at an observation site is a linear response to an input somewhere upstream the arterial flow. The corresponding impulse response functions are currently treated empirically without incorporating the relation to the vascular morphology of an organ. I...
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Dynamic PET reconstruction is a challenging issue due to the spatio-temporal nature and the complexity of the data. Conventional frame-by-frame approaches fail to explore the temporal information of dynamic PET data, and may lead to inaccurate results due to the low SNR of data. Due to the ill-conditioning of image reconstruction, proper prior knowledge should be incorporated to constrain the r...
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ژورنال
عنوان ژورنال: Mathematical Modelling
سال: 1986
ISSN: 0270-0255
DOI: 10.1016/0270-0255(86)90111-9